Pyrrolidine → HCID 18663595, compound

HRID 1956580Notes

Reaction equation

HRID 1956580 reaction equation
Br[CH2:2][C:3]1[C:9]2[CH:10]=[CH:11][C:12]([Cl:14])=[CH:13][C:8]=2[O:7][C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[CH:4]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[ClH:14].[Cl:14][C:12]1[CH:11]=[CH:10][C:9]2[C:3]([CH2:2][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:4][C:5]3[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=3[O:7][C:8]=2[CH:13]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 18663587HCID 18663587, compound

Product 1

HCID 18663595HCID 18663595, compoundYield 5%

Procedure

Preparation analogous to Example 2 from 10-bromomethyl-7-chloro-dibenz[b,f]oxepine and pyrrolidine. Yield: 5%, melting point:>225° C. decomposition. 1H-NMR (CD3OD, 200 MHz): 1.95-2.20 (m, 4H); 3.25 (m 2H); 3.55 (m, 2H), 4.52 (s, 2H), 7.20-7.45 (m, 7H); 7.60 (d, 1H). MS: 311 (M+, free base), 244, 242, 241, 215, 205, 178, 176, 163, 152.

Sources & evidence

ORD record
ord-afb17a719d574af9a75743b163b3c45e
Source dataset
uspto-grants-1998_07
Patent number
US05780500

Reaction notes

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