Methyl Nicotinate → HCID 14576266, compound

Temperature

23 °C

A solution of potassium tert-butoxide (83.55 g) in tetrahydrofuran (500 ml) at 22° C. is treated, dropwise, with a solution of methyl nicotinate (68.5 g) and delta-valerolactone (75.0 g) in tetrahydrofuran (125 ml) during a period of 1 hour. The solution is then stirred at 23° C. for 2 hours. The reaction mixture is diluted with water and washed with toluene (125 ml). The organic phase is discarded and the aqueous phase is treated dropwise with concentrated hydrochloric acid (400 ml;37% w/v). The solution Is stirred for a further 2 hours. The solution is then washed with dichloromethane (250 ml). The organic phase is discarded and the aqueous phase is treated with aqueous sodium hydroxide solution to bring it to between pH8 and pH9. The aqueous phase is then washed with toluene (125 ml) and the organic phase is back washed with water (3×100 ml). The two aqueous phases are combined and extracted with dichloromethane. The dichloromethane extract is dried over magnesium sulphate, and evaporated to dryness, to give 4-hydroxybutyl 3-pyridyl ketone (61.1 g) in the form of an oil which crystallises to form a pale brown solid, m.p. 36°-38° C. [NMR (CDCl3):- 1.7(m,2H),1.9(m,2H),3.1(t,2H),3.7(t,2H),7.4(m,1H), 8.2(dt,1H),8.8(m,1H),9.2(m,1H)].

1. washwashed with toluene (125 ml)
2. additionthe aqueous phase is treated dropwise with concentrated hydrochloric acid (400 ml;37% w/v)
3. stirringThe solution Is stirred for a further 2 hours
4. washThe solution is then washed with dichloromethane (250 ml)
5. additionthe aqueous phase is treated with aqueous sodium hydroxide solution
6. washThe aqueous phase is then washed with toluene (125 ml)
7. washthe organic phase is back washed with water (3×100 ml)
8. extractionextracted with dichloromethane
9. extractionThe dichloromethane extract
10. dry with materialis dried over magnesium sulphate
11. customevaporated to dryness

ORD record

ord-2e4a19a68cf249309c3993c68e2a2844

Source dataset

uspto-grants-1998_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05780636