Potassium Carbonate → 4-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperid-1-yl]ethyl]morpholine hydrochloride monohydrate

HRID 1957074Notes

Reaction equation

HRID 1957074 reaction equation
O.[ClH:2].[C:3](N1CCOC(C2C=CC(F)=C(F)C=2)(CCN2CCC(NC(N(C)C)=O)(C3C=CC=CC=3)CC2)C1)(=[O:10])[C:4]1C=CC=CC=1.[C:45]([N:53]1[CH2:58][CH2:57][O:56][C:55]([CH2:67][CH2:68][N:69]2[CH2:74][CH2:73][C:72]([C:81]3[CH:86]=[CH:85][CH:84]=[CH:83][CH:82]=3)([NH:75][C:76]([N:78]([CH3:80])[CH3:79])=[O:77])[CH2:71][CH2:70]2)([C:59]2[CH:64]=[CH:63][C:62]([F:65])=[C:61]([F:66])[CH:60]=2)[CH2:54]1)(=[O:52])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1.Cl.C1(S(O)(=O)=O)C=CC=CC=1.C1(C2(NC(N3CCCC3)=O)CCNCC2)C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[OH2:10].[ClH:2].[C:45]([N:53]1[CH2:58][CH2:57][O:56][C:55]([C:59]2[CH:64]=[CH:63][C:62]([F:65])=[C:61]([F:66])[CH:60]=2)([CH2:67][CH2:68][N:69]2[CH2:74][CH2:73][C:72]([C:81]3[CH:82]=[CH:83][CH:84]=[CH:85][CH:86]=3)([NH:75][C:76]([N:78]3[CH2:80][CH2:4][CH2:3][CH2:79]3)=[O:77])[CH2:71][CH2:70]2)[CH2:54]1)(=[O:52])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 212004754-Phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperidine benzenesulfonateHCID 1317200584-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-(N',N'-dimethylureido)-4-phenylpiperid-1-yl]ethyl]morpholine hydrochloride hemihydrate

Product 1

HCID 212006404-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperid-1-yl]ethyl]morpholine hydrochloride monohydrateYield 47.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperidine benzenesulfonate, 1.2 g of K2CO3 and 2 ml of DMF to give 0.3 g of the expected product. M.p.=163°-168° C.

Workup

  1. customThis compound is prepared by the procedure

Sources & evidence

ORD record
ord-96537224f63d4e35bcacd2db7a421b05
Source dataset
uspto-grants-1998_07
Patent number
US05780466

Reaction notes

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