HRID1957076

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(S(=O)(=O)O)cc1.Nc1nnc(C2(c3ccccc3)CCNCC2)o1

HCID22741723

未命名化合物

结构：CN(C)C(=O)NC1(c2ccccc2)CCN(CCC2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1.CN(C)C(=O)NC1(c2ccccc2)CCN(CCC2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1.Cl.Cl.O

HCID131720058

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.Nc1nnc(C2(c3ccccc3)CCN(CCC3(c4ccc(F)c(F)c4)CN(C(=O)c4ccccc4)CCO3)CC2)o1

HCID21200463

未命名化合物

收率 192.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-(2-amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperidine p-toluenesulfonate, 1.2 g of K2CO3 and 3 ml of DMF to give 0.6 g of the expected product. M.p.=153° C.

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5b7b30bd50d44a0876d0c1c88549b1c
来源数据集: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05780466
来源说明: uspto-grants-1998_07

反应 SMILES

O.[ClH:2].[C:3]([N:11]1[CH2:16][CH2:15][O:14][C:13]([C:37]2[CH:42]=[CH:41][C:40]([F:43])=[C:39]([F:44])[CH:38]=2)([CH2:17][CH2:18]N2CCC(NC(N(C)C)=O)(C3C=CC=CC=3)CC2)[CH2:12]1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(N1CCOC(CCN2CCC(C3C=CC=CC=3)(NC(N(C)C)=O)CC2)(C2C=CC(F)=C(F)C=2)C1)(=O)C1C=CC=CC=1.Cl.C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:99][C:100]1[O:101][C:102]([C:105]2([C:111]3[CH:116]=[CH:115][CH:114]=[CH:113][CH:112]=3)[CH2:110][CH2:109][NH:108][CH2:107][CH2:106]2)=[N:103][N:104]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:2].[ClH:2].[NH2:99][C:100]1[O:101][C:102]([C:105]2([C:111]3[CH:116]=[CH:115][CH:114]=[CH:113][CH:112]=3)[CH2:106][CH2:107][N:108]([CH2:18][CH2:17][C:13]3([C:37]4[CH:42]=[CH:41][C:40]([F:43])=[C:39]([F:44])[CH:38]=4)[O:14][CH2:15][CH2:16][N:11]([C:3](=[O:10])[C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH2:12]3)[CH2:109][CH2:110]2)=[N:103][N:104]=1