Potassium Carbonate → 2-[2-[4-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperid-1-yl]ethyl]-4-benzoyl-2-(3,4-difluorophenyl)morpholine dihydrochloride

HRID 1957076Notes

Reaction equation

HRID 1957076 reaction equation
O.[ClH:2].[C:3]([N:11]1[CH2:16][CH2:15][O:14][C:13]([C:37]2[CH:42]=[CH:41][C:40]([F:43])=[C:39]([F:44])[CH:38]=2)([CH2:17][CH2:18]N2CCC(NC(N(C)C)=O)(C3C=CC=CC=3)CC2)[CH2:12]1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(N1CCOC(CCN2CCC(C3C=CC=CC=3)(NC(N(C)C)=O)CC2)(C2C=CC(F)=C(F)C=2)C1)(=O)C1C=CC=CC=1.Cl.C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:99][C:100]1[O:101][C:102]([C:105]2([C:111]3[CH:116]=[CH:115][CH:114]=[CH:113][CH:112]=3)[CH2:110][CH2:109][NH:108][CH2:107][CH2:106]2)=[N:103][N:104]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:2].[ClH:2].[NH2:99][C:100]1[O:101][C:102]([C:105]2([C:111]3[CH:116]=[CH:115][CH:114]=[CH:113][CH:112]=3)[CH2:106][CH2:107][N:108]([CH2:18][CH2:17][C:13]3([C:37]4[CH:42]=[CH:41][C:40]([F:43])=[C:39]([F:44])[CH:38]=4)[O:14][CH2:15][CH2:16][N:11]([C:3](=[O:10])[C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH2:12]3)[CH2:109][CH2:110]2)=[N:103][N:104]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 227417234-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperidine p-toluenesulfonateHCID 1317200584-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-(N',N'-dimethylureido)-4-phenylpiperid-1-yl]ethyl]morpholine hydrochloride hemihydrate

Product 1

HCID 212004632-[2-[4-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperid-1-yl]ethyl]-4-benzoyl-2-(3,4-difluorophenyl)morpholine dihydrochlorideYield 192.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-(2-amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperidine p-toluenesulfonate, 1.2 g of K2CO3 and 3 ml of DMF to give 0.6 g of the expected product. M.p.=153° C.

Workup

  1. customThis compound is prepared by the procedure

Sources & evidence

ORD record
ord-b5b7b30bd50d44a0876d0c1c88549b1c
Source dataset
uspto-grants-1998_07
Patent number
US05780466

Reaction notes

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