HCID 10617092, compound → HCID 10710202, compound

HRID 1957108Notes

Reaction equation

HRID 1957108 reaction equation
[Cl:1][C:2]1[C:3]([CH2:17][N:18]2[CH:22]=[N:21][CH:20]=[N:19]2)=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([O:13]C)[C:6]([O:15]C)=[N:5]2>Cl.O1CCOCC1>[Cl:1][C:2]1[C:3]([CH2:17][N:18]2[CH:22]=[N:21][CH:20]=[N:19]2)=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[NH:8][C:7](=[O:13])[C:6](=[O:15])[NH:5]2

Participants

4

Reactant 1

HCID 10617092HCID 10617092, compound

Product 1

HCID 10710202HCID 10710202, compoundYield 66.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

6,7-Dichloro-2,3-dimethoxy-5-(1,2,4-triazol-1-ylmethyl)-quinoxaline (99 mg, 0.29 mmol) was heated in a mixture of 2M hydrochloric acid (2 mL) and dioxane (2 mL) at reflux for 3 hours. The solvent was removed under reduced pressure and the solid residue was suspended in water and filtered to give 1,4-dihydro-6,7dichloro-5-(1,2,4-triazol-1-ylmethyl)-quinoxalin-2,3-dione (60 mg, 62%) as a white solid, mp>320° C. Found: C, 39.47; H 2.49; N, 20.54. C11H7Cl2N5O2.1.25.H2O requires C, 39.48; H 2.86; N, 20.93%.

Workup

  1. temperatureat reflux for 3 hours
  2. customThe solvent was removed under reduced pressure
  3. filtrationfiltered

Sources & evidence

ORD record
ord-1ebcc5b5a4874635aa8c3727da1e2da6
Source dataset
uspto-grants-1998_07
Patent number
US05783572

Reaction notes

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