反应详情

A solution of sodium methoxide (38 mL , 25% solution in methanol, 175 mmol) was added over 10 minutes to a solution of 5-methyl-2,3,6,7-tetrachloroquinoxaline (21 g, 74 mmol) in dry tetrahydrofuran (200 mL) at 20° C. There was a mildly exothermic reaction followed by formation of a precipitate. After 1 hour the mixture was diluted with ethyl acetate (3 L), washed with water (1 L), dried (MgSO4) and concentrated under reduced pressure to give 6,7dichloro-2,3-dimethoxy-5-methylquinoxaline (20.3 g, 100%).

1. customa mildly exothermic reaction
2. washwashed with water (1 L)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated under reduced pressure