Dimethylamine → HCID 67667357, compound

HRID 1957177Notes

Reaction equation

HRID 1957177 reaction equation
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6](Cl)[N:5]=[C:4]([CH3:14])[N:3]=1.C(C1C=C(O)C=CC=1)(C)C.C(=O)([O-])[O-].[K+].[K+].[CH3:31][NH:32][CH3:33]>CN(C)C=O.O>[CH3:31][N:32]([CH3:33])[N:5]1[CH:6]=[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:2]=[N:3][CH:4]1[CH3:14]

Participants

7

Reactant 4

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 120593-IsopropylphenolHCID 19071353HCID 19071353, compound

Product 1

HCID 67667357HCID 67667357, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Methyl 4,6-dichloro-2-methyl-pyrimidin-5-yl-acetate (23.5 g, 0.1 mol), 3-isopropylphenol (13.6 g, 0.1 mol) and potassium carbonate (20.7 g, 0.15 mol) are heated in dimethylformamide (30 ml) at 100° C. for 45 minutes. The mixture is cooled and an aqueous solution of dimethylamine (50 ml of a 40% solution) is added. Stirring is continued for 16 hours at room temperature. Addition of water, filtering and drying gives the methyl 1-dimethylamino-2-methyl-pyrimidin-5-yl-acetate as a brownish solid (28 g).

Workup

  1. temperatureThe mixture is cooled
  2. filtrationfiltering
  3. customdrying

Sources & evidence

ORD record
ord-a670d7abaf4c445c8307aea3b7a4ee8b
Source dataset
uspto-grants-1998_07
Patent number
US05783580

Reaction notes

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