Dimethylformamide → HCID 19068945, compound

HRID 1957201Notes

Reaction equation

HRID 1957201 reaction equation
O=P(Cl)(Cl)[Cl:3].[CH3:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[Cl:16])[CH2:9][C:8]1=O.CN([CH:21]=[O:22])C>>[CH3:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[Cl:16])[C:9]([CH:21]=[O:22])=[C:8]1[Cl:3]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 149184547-Chloro-1-methyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 19068945HCID 19068945, compoundYield 72%

Procedure

Prepared from POCl3 (17 ml), DMF (17 ml), (44) (7.5 g), yielding (47) 6.8 g (72%). M.p. 185°-187° C. In this reaction the reaction time was 48 h instead of 3 h.

Sources & evidence

ORD record
ord-dd428eec99dc457588ad242fff2fe64e
Source dataset
uspto-grants-1998_07
Patent number
US05783575

Reaction notes

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