Water → HCID 19068974, compound

HRID 1957223Notes

Reaction equation

HRID 1957223 reaction equation
[SH:1][CH2:2][C:3]([O:5][CH3:6])=[O:4].Cl[C:8]1[N:9]([CH2:19][O:20][CH2:21][CH2:22][O:23][CH3:24])[C:10]2[C:15]([C:16]=1[CH:17]=O)=[CH:14][CH:13]=[CH:12][CH:11]=2.C([O-])([O-])=O.[K+].[K+].O>CO>[CH3:24][O:23][CH2:22][CH2:21][O:20][CH2:19][N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:16]2[CH:17]=[C:2]([C:3]([O:5][CH3:6])=[O:4])[S:1][C:8]1=2

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 19068975HCID 19068975, compound

Product 1

HCID 19068974HCID 19068974, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

400 μl of methyl 2-mercaptoacetate was added to a slurry of 1 g of (78) and 1.1 g of K2CO3 in 10 ml of MeOH. The reaction was stirred overnight, and then 20 ml of water was added. The mixture was extracted with EtOAc, and the organic layer washed with water, dried and evaporated to give (79) as a yellow oil. Yield 880 mg.

Workup

  1. extractionThe mixture was extracted with EtOAc
  2. washthe organic layer washed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-eea63e5a924641959dfc9db297215fca
Source dataset
uspto-grants-1998_07
Patent number
US05783575

Reaction notes

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