Water → HCID 19068938, compound

HRID 1957225Notes

Reaction equation

HRID 1957225 reaction equation
[SH:1][CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:7]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:19][O:20][CH2:21][CH2:22][O:23][CH3:24])[C:11]=1Cl)(=O)[CH3:8].C([O-])([O-])=O.[K+].[K+].O>CO>[CH3:24][O:23][CH2:22][CH2:21][O:20][CH2:19][N:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]2[C:7]([CH3:8])=[C:2]([C:3]([O:5][CH3:6])=[O:4])[S:1][C:11]1=2

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 19068948HCID 19068948, compound

Product 1

HCID 19068938HCID 19068938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

400 μl of methyl 2-mercaptoacetate was added to a slurry of 1050 mg of (80) and 1.1 g of K2CO3 in 10 ml of MeOH, and left with stirring for 48 hours. 20 ml of water was added, and the precipitate filtered off and dried. This material was thoroughly washed with pentane, filtered, dried, and recrystallized from EtOH giving 230 mg of (81) as a white powder. M.p. 85.4°-86° C.

Workup

  1. waitleft
  2. filtrationthe precipitate filtered off
  3. customdried
  4. washThis material was thoroughly washed with pentane
  5. filtrationfiltered
  6. customdried
  7. customrecrystallized from EtOH giving 230 mg of (81) as a white powder

Sources & evidence

ORD record
ord-9e1f20642ab1413397e3420dfa31e5db
Source dataset
uspto-grants-1998_07
Patent number
US05783575

Reaction notes

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