Dimethylformamide → HCID 19068747, compound

HRID 1957252Notes

Reaction equation

HRID 1957252 reaction equation
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([SH:19])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[CH2:31](Br)[C:32]#[CH:33]>O>[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([S:19][CH2:33][C:32]#[CH:31])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:7]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 19068744HCID 19068744, compound

Product 1

HCID 19068747HCID 19068747, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.0 g of 3-chloro-2-(4-chloro-3-mercaptophenyl)-5-trifluoromethylpyridine (prepared as in Example 33) and 2.1 g of potassium carbonate were introduced into 50 ml of anhydrous dimethylformamide amide at 23° C. After a dropwise addition of 0.73 g of propargyl bromide, the mixture was stirred for 16 h and then poured into 300 ml of water. After 30 minutes, the crystals which had formed were removed, washed with water and dried.

Workup

  1. waitAfter 30 minutes
  2. customthe crystals which had formed
  3. customwere removed
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-dc0d8008006a4c2eb564a692510ab66f
Source dataset
uspto-grants-1998_07
Patent number
US05783522

Reaction notes

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