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0 °C

A small piece of sodium was added to a solution of 4.0 g of 3-chloro-2-(4-chloro-3-methoxycarbonylphenyl)-5-trifluoromethylpyridine in 20 ml of anhydrous isopropanol, followed by stirring at 0° C. for 20 hours. The solvent was then removed. The residue was taken up in 50 ml of water. The aqueous phase was extracted three times with 50 ml of tert-butyl methyl ether each time. The combined organic phases were dried over sodium sulfate and concentrated. Yield: 2.5 g (58%) of a colorless oil;

1. customThe solvent was then removed
2. extractionThe aqueous phase was extracted three times with 50 ml of tert-butyl methyl ether each time
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. concentrationconcentrated