Aluminium lithium hydride → HCID 57075766, compound

HRID 1957353Notes

Reaction equation

HRID 1957353 reaction equation
[C:1]([NH:5][C@H:6]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)[CH2:7][CH2:8][CH3:9])(=O)[CH2:2][CH3:3].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH2:1]([NH:5][C@H:6]([C:10]1[CH:11]=[CH:12][C:13]([O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:15]=1)[CH2:7][CH2:8][CH3:9])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57283832HCID 57283832, compound

Product 1

HCID 57075766HCID 57075766, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

The butylamine prepared above (57 mg, 0.21 mmol) in THF (1 mL) at room temperature was treated with 1M LAH in THF (0.42 mL). The solution was warmed to reflux for 4 hours, cooled to 0° C. and quenched with sodium sulfate decahydrate. The slurry was filtered through celite and concentrated to provide 53 mg (99%) of the title compound as a colorless oil.

Workup

  1. temperatureThe solution was warmed
  2. temperatureto reflux for 4 hours
  3. customquenched with sodium sulfate decahydrate
  4. filtrationThe slurry was filtered through celite and
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-532a1c5cbb4a4d598a1ea2ed7937c4c7
Source dataset
uspto-grants-1998_07
Patent number
US05783593

Reaction notes

Loading…