Potassium Hydroxide → HCID 2776764, compound

HRID 1957523Notes

Reaction equation

HRID 1957523 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][CH3:10].[OH-:12].[K+].Cl.[NH2:15]O>Cl>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[N:15][OH:12])[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 691332'-HydroxypropiophenoneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 2776764HCID 2776764, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

15 g of 1-(2-hydroxyphenyl)-1-propanone are added dropwise to 170 ml of a 40% aqueous solution of potassium hydroxide. To this emulsion are then added, in increments, 31.2 g of hydroxylamine hydrochloride and the mixture is stirred for 4 h at 0°-5° C. The reaction mixture is then acidified with 150 ml of concentrated hydrochloric acid, the precipitated product is isolated by filtration, washed with water and dried, giving 1-(2-hydroxyphenyl)-1-propanone oxime having a melting point of 88°-90° C.

Workup

  1. customthe precipitated product is isolated by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-86e6a31eeac947eab151670790e1f62b
Source dataset
uspto-grants-1998_07
Patent number
US05786374

Reaction notes

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