Pyridine → HCID 136351318, compound

HRID 1957531Notes

Reaction equation

HRID 1957531 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](=O)[CH3:11])=[N:2]1.Cl.[NH2:14][OH:15].N1C=CC=CC=1>C(OCC)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](=[N:14][OH:15])[CH3:11])=[N:2]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 127064081-(1,2-Benzoxazol-3-yl)ethan-1-one

Product 1

HCID 136351318HCID 136351318, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1.4 g of 1-(1,2-benzisoxazol-3-yl)ethanone, 0.7 g of hydroxylamine hydrochloride and 10 ml of pyridine is refluxed for 1 h. The reaction mixture is then poured onto a mixture of ice/water and the precipitated product is isolated by filtration. The product is dissolved in ethyl acetate, the solution is washed once with water, then twice with a saturated solution of sodium chloride and finally dried over sodium sulfate. The solvent is stripped off under vacuum, to give pure 1-(1,2-benzisoxazol-3-yl)ethanone oxime having a melting point of 193°-195° C.

Workup

  1. temperatureis refluxed for 1 h
  2. customthe precipitated product is isolated by filtration
  3. washthe solution is washed once with water
  4. dry with materialtwice with a saturated solution of sodium chloride and finally dried over sodium sulfate

Sources & evidence

ORD record
ord-2f2d78f60f034b47b3f651c5172c5756
Source dataset
uspto-grants-1998_07
Patent number
US05786374

Reaction notes

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