反应详情

700 mg (3.95 mmol) of allyl 4-aminobenzoate, 1 ml (4.3 mmol) of triethylamine and 50 ml of THF were introduced into a round-bottomed flask. A solution of 1.5 g (3.96 mmol) of 3-(1-adamantyl)-4-methoxyethoxymethoxybenzoyl chloride was added dropwise and the mixture was stirred at room temperature for 4 hours. The reaction medium was poured into water and extracted with ethyl ether. The organic phase was separated out after settling had taken place, dried over magnesium sulfate and evaporated. The residue obtained was purified by chromatography on a column of silica, eluted with dichloromethane. 1.7 g (83%) of the expected allylic ester was recovered in the form of an oil.

1. extractionextracted with ethyl ether
2. customThe organic phase was separated out
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue obtained
6. customwas purified by chromatography on a column of silica
7. washeluted with dichloromethane
8. custom1.7 g (83%) of the expected allylic ester was recovered in the form of an oil