Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 67506229, compound
Reaction equation
[CH3:1][C:2]1[C:6]([CH3:8])([CH3:7])[CH:5]([CH2:9][CH:10]=O)[CH2:4][CH:3]=1.[C:12]([CH:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13]>C(OC)(C)(C)C>[CH3:8][C:6]1([CH3:7])[C:2]([CH3:1])=[CH:3][CH2:4][CH:5]1[CH2:9][CH:10]=[CH:17][C:12]([O:14][CH2:15][CH3:16])=[O:13]Participants
Conditions
- Temperature
- 0 °C
Procedure
To a flame-dried 250 ml round bottom flask campholenic aldehyde (10.0 g, 65.7 mmol) and methyl tertiary-butyl ether (MTBE) (100 ml) were added to give a solution and the flask was slowly cooled to 0° C. in an ice water bath. (Carbethoxymethylene)triphenyl-phosphorane (22.8 g, 66.0 mmol) was slowly added to the solution. The reaction mixture was stirred at 0° C. for 20 min then stirred at room temperature for about 24 h. After the reaction was completed, the reaction mixture was reduced to half its volume in vacuo and 100 ml of hexanes was added. The flask containing the reaction mixture and hexanes was then placed in an ice bath for 30 min. The reaction mixture was then filtered through a plug of filter paper, celite, silica, and sand and washed three times, first with hexanes, then 9:1 and then 1:1 Hexanes/MTBE. The combined eluates were concentrated in vacuo and purifed via flash column chromatography (1:8 Hexanes/Ethyl Acetate (AcOEt)) to give ethyl 4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoate (13.1 g, 89%) as an oil. The NMR data is indicated below.
Workup
- customto give a solution
- stirringthen stirred at room temperature for about 24 h
- additionwas added
- waitwas then placed in an ice bath for 30 min
- filtrationThe reaction mixture was then filtered through a plug of filter paper, celite, silica, and sand
- washwashed three times
- concentrationThe combined eluates were concentrated in vacuo
Sources & evidence
- ORD record
- ord-7b5553e568124f32b67dbd33f5c1ebbd
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08409649B2
Reaction notes
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