Water → Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

HRID 1957927Notes

Reaction equation

HRID 1957927 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[CH:4]=[C:3]1[C:10](=[O:15])C(Cl)(Cl)Cl.C(N([CH2:21][CH3:22])CC)C.[OH2:23]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[CH:4]=[C:3]1[C:10]([O:15][CH2:21][CH3:22])=[O:23]

Participants

5

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 27599662,2,2-Trichloro-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)ethan-1-one

Product 1

HCID 10442704Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.50 g (1.84 mmol) of 1-methyl-4-nitro-2-trichloroacetyl-1H-pyrrole are initially charged in 5 ml of ethanol, 0.26 ml (1.84 mmol) of triethylamine are added and the mixture is stirred at RT for 2 h. 5 ml of water are added, the reaction mixture is stirred at 0° C. for 30 min and the precipitate is then filtered off with suction and dried under reduced pressure.

Workup

  1. stirringthe reaction mixture is stirred at 0° C. for 30 min
  2. filtrationthe precipitate is then filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-0c3d305414ec4f61836c887c423bf3b0
Source dataset
uspto-grants-2013_04
Patent number
US08410090B2

Reaction notes

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