Lithium Hydroxide → HCID 59363504, compound

HRID 1957929Notes

Reaction equation

HRID 1957929 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[O:9])[CH:4]=[C:3]1[C:22]([O:24]CC)=[O:23].[OH-].[Li+]>C1COCC1.O>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:20])([F:21])[F:19])=[CH:15][CH:16]=2)=[O:9])[CH:4]=[C:3]1[C:22]([OH:24])=[O:23]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 59363501HCID 59363501, compound

Product 1

HCID 59363504HCID 59363504, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

470 mg (1.27 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate are initially charged in 5 ml of THF, 152 mg (6.33 mmol) of lithium hydroxide in 1 ml of water are added and the mixture is stirred under reflux overnight. The reaction mixture is concentrated, the residue is acidified with 2M hydrochloric acid and the precipitate formed is filtered off with suction and dried under reduced pressure. This gives a solid.

Workup

  1. temperatureunder reflux overnight
  2. concentrationThe reaction mixture is concentrated
  3. customthe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried under reduced pressure
  6. customThis gives a solid

Sources & evidence

ORD record
ord-ca89fc13e2a14b1f8278ccb967f19dcb
Source dataset
uspto-grants-2013_04
Patent number
US08410090B2

Reaction notes

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