Tetrahydrofuran → HCID 49778924, compound

HRID 1958026Notes

Reaction equation

[C:1]([C:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:5][C:4]=1[N:14]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[C:20]=1[CH3:29])[C:15](=O)[CH3:16])#[N:2].B1([O-])O[O:31]1.O.O.O.O.[Na+].C(=O)([O-])[O-].[K+].[K+].O1CCCC1>CO.O>[CH3:16][C:15]1[N:14]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:26])([F:27])[F:28])[C:20]=2[CH3:29])[C:4]2[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[S:7][C:3]=2[C:1](=[O:31])[N:2]=1

Participants

Conditions

Temperature: 55 °C

Procedure

In a 2 L round bottom flask equipped with a magnetic stir bar, N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide (42.5 g, 100 mmol), sodium perborate tetrahydrate (46.2 g, 300 mmol), and potassium carbonate (27.64 g, 200 mmol) were taken up in Methanol (233 mL), Tetrahydrofuran (THF) (233 mL), and Water (233 mL) and the resulting reaction mixture was heated to 55° C. and stirred overnight at 55° C.

Workup

customIn a 2 L round bottom flask equipped with a magnetic stir bar

Sources & evidence

ORD record: ord-797bb9ad910948aeb3f06d9dd08eb73f
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08410095B2

Reaction notes

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