Phenylboronic Acid → N-(5-phenyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

HRID 1958188Notes

Reaction equation

HRID 1958188 reaction equation
Br[C:2]1[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([C:2]2[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=3)[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 67280716N-(5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

Product 1

HCID 56961949N-(5-phenyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 39, using N-[5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide (example G) and B-phenyl-boronic acid (CAN 98-80-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 374.1107 (M+H)+.

Sources & evidence

ORD record
ord-732b21510e4b4257a7b00ca36899a0eb
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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