Hydrochloric Acid → HCID 86657901, compound

HRID 1958348Notes

Reaction equation

HRID 1958348 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][F:14])C)(C)(C)C.[ClH:16]>O1CCOCC1>[ClH:16].[F:14][CH2:13][CH2:12][O:11][CH2:10][CH2:9][NH:7][CH3:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86657900HCID 86657900, compound

Product 1

HCID 86657901HCID 86657901, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of [2-(2-fluoro-ethoxy)-ethyl]-methyl-carbamic acid tert-butyl ester (2.00 g, 0.05 mmol) in dry 1,4-dioxane (20 ml) was added 4M HCl in 1,4-dioxane (22.6 ml, 90 mmol) dropwise at 0° C. The reaction mixture was stirred at RT for 5 h. Volatiles were removed under vacuum. The crude material was washed with hexane and dried under vacuum to give desired product [2-(2-fluoro-ethoxy)-ethyl]-methyl-amine hydrochloride as pale yellow solid (1.2 g, 84%).

Workup

  1. customVolatiles were removed under vacuum
  2. washThe crude material was washed with hexane
  3. customdried under vacuum

Sources & evidence

ORD record
ord-152914314b9e487687bec6c393c272ec
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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