反应详情

Ethyl 5-(2-(3-(2-fluoro ethoxy)phenyl)imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylate (100 mg, 221 μmol) was combined with Ethanol (0.570 ml) and THF (0.570) to give a yellow solution. The reaction was stirred at RT for 6 h. H2O was added to the suspension and then HCl 1N was added until the mixture was acidic (pH=3). The suspension was stirred for 30 min and then the reaction mixture was filtered. The residual solvent was removed under vacuum. The title compound was obtained as a light yellow solid (73 mg, 78%).

1. customto give a yellow solution
2. stirringThe suspension was stirred for 30 min
3. filtrationthe reaction mixture was filtered
4. customThe residual solvent was removed under vacuum