Isobutyl chloroformate → HCID 57496371, compound

HRID 1958412Notes

Reaction equation

HRID 1958412 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][CH2:15][CH:11]([C:12]([OH:14])=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(Cl)=O)C(C)C.[CH3:25][N:26]([CH3:30])[CH2:27][CH2:28][NH2:29]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:12](=[O:14])[NH:29][CH2:28][CH2:27][N:26]([CH3:30])[CH3:25])[CH2:15][CH2:16]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 62365Isobutyl chloroformateHCID 66053N,N-DimethylethylenediamineHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

Product 1

HCID 57496371HCID 57496371, compound

Procedure

4-(2-Dimethylamino-ethylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester was prepared from 1-t-butoxycarbonyl-iso-nipecotic acid (5 g), iso-butylchloroformate (2.83 mL) and N,N-dimethyl-1,2-ethylenediamine (2.63 mL). Exact mass calculated for C15H29N3O3 299.22, found 300.4 (MH+).

Sources & evidence

ORD record
ord-8a090fcf744b4f28919a5d9390cf41c6
Source dataset
uspto-grants-2013_04
Patent number
US08410119B2

Reaction notes

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