反应详情

温度

60 °C

H2O2 (0.056 mL, 30% in H2O) was added to a stirred solution of 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfinyl)ethyl]-1-naphthalenecarboxamide (i.e. the product of Example 2, 100 mg) in acetic acid (1.0 mL). The reaction mixture was stirred at 60° C. for 4 h, then cooled to room temperature, diluted with water, adjusted to pH 4 with 1.0 M aqueous NaOH solution, and extracted with chloroform. The organic extract was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure to provide the title compound (100 mg), a compound of this invention, as a white solid. 1H NMR (CDCl3): δ 8.80 (d, 1H), 8.29 (d, 1H), 7.43-7.66 (m, 7H), 6.94 (br t, 1H), 4.24 (d, 1H), 4.04 (q, 2H), 3.40 (t, 2H), 3.01 (s, 3H).

1. temperaturecooled to room temperature
2. extractionextracted with chloroform
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure