Triethylamine → HCID 86619886, compound

HRID 1959029Notes

Reaction equation

HRID 1959029 reaction equation
[CH:1]([O:4][CH2:5][C@@H:6]([OH:9])[CH2:7][OH:8])([CH3:3])[CH3:2].[Si:10](Cl)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11].C(N(CC)CC)C>C(Cl)Cl.CN(C)C1C=CN=CC=1>[Si:10]([O:8][CH2:7][C@H:6]([OH:9])[CH2:5][O:4][CH:1]([CH3:3])[CH3:2])([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 28928tert-Butyldimethylsilyl chlorideHCID 53628390HCID 53628390, compound2×

Product 1

HCID 86619886HCID 86619886, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

The subtitle compound was prepared according to the procedure outlined in example 34 step iii) using (2S)-3-isopropoxypropane-1,2-diol (0.80 g) (the product from step (ii) in DCM (10 mL), tert-butyldimethylsilyl chloride (1.59 g), triethylamine (1.43 mL) and 4-(dimethylamino)pyridine (50 mg) at 0° C. to give the subtitle compound as a clear, colourless oil. Yield: 1.86 g

Workup

  1. customThe subtitle compound was prepared
  2. customat 0° C.

Sources & evidence

ORD record
ord-ae727251f67b4b289eeba47a5d9a5fe1
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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