反应详情

3-(5-phenyl-1,3,4-oxadiazol-2-yl)-5-(1,2,3,6-tetrahydropyridin-4-yl)pyrazin-2-amine (50 mg, 0.1151 mmol) was dissolved in DCM (3 mL) and Et3N (34.94 mg, 48.13 μL, 0.3453 mmol) followed by ethanesulfonyl chloride (16.28 mg, 12.00 μL, 0.1266 mmol) were added. The reaction was allowed to stir for 30 mins and then diluted with dichloromethane and washed with water. The aqueous layer was extracted further with dichloromethane and the organics washed with saturated aqueous NaHCO3, dried over MgSO4 and concentrated in vacuo. The resultant residue was purified on silica gel by flash column chromatography (0-5% MeOH/DCM) to afford the title compound (47.47 mg, 60% Yield).

1. additionwere added
2. washwashed with water
3. extractionThe aqueous layer was extracted further with dichloromethane
4. washthe organics washed with saturated aqueous NaHCO3
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo
7. customThe resultant residue was purified on silica gel by flash column chromatography (0-5% MeOH/DCM)