3-(5-Fluoro-2-methoxy-phenylamino)-but-2-enoic acid ethyl ester → HCID 178491787, compound

HRID 1959547Notes

Reaction equation

HRID 1959547 reaction equation
C(O[C:4](=[O:18])[CH:5]=[C:6]([NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[O:16][CH3:17])[CH3:7])C>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]2[C:14]=1[C:4]([OH:18])=[CH:5][C:6]([CH3:7])=[N:8]2

Participants

4

Reactant 1

HCID 670780423-(5-Fluoro-2-methoxy-phenylamino)-but-2-enoic acid ethyl ester

Product 1

HCID 178491787HCID 178491787, compound

Reagents, catalysts & solvents 2

HCID 7583Diphenyl EtherSolventHCID 8058HexaneSolvent

Procedure

A solution of 3-(5-fluoro-2-methoxy-phenylamino)-but-2-enoic acid ethyl ester (1.8 g, 6.7 mmol) in diphenyl ether (10.7 mL) was heated to 250° C. for 25 min. The reaction mixture was cooled to room temperature, diluted with hexane, and filtered to give the title compound. MS (m/z): 208.1 [M+H+].

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-f48f5265a5924725b2420533940429ad
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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