Carbon Tetrachloride → HCID 67078081, compound

HRID 1959556Notes

Reaction equation

HRID 1959556 reaction equation
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:20]([Cl:24])(Cl)(Cl)Cl.[CH3:25][O:26][C:27](=[O:37])[C:28]1[C:33](CO)=[C:32]([Cl:36])[CH:31]=[N:30][CH:29]=1>C(Cl)Cl>[CH3:25][O:26][C:27](=[O:37])[C:28]1[C:33]([CH2:32][Cl:36])=[C:20]([Cl:24])[CH:31]=[N:30][CH:29]=1

Participants

5

Reactant 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 67077247HCID 67077247, compound

Product 1

HCID 67078081HCID 67078081, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Polymer bound triphenylphosphine (3 mmol/g, 234 mg, 0.702 mmol) and CCl4 (400 μL) were added to a stirred solution of 5-chloro-4-hydroxymethyl-nicotinic acid methyl ester (14.2 mg, 0.070 mmol) in DCM (4 mL). After stirring for 2 h at room temperature, the reaction mixture was filtered and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 220.1 [M+H+].

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customThe resulting title compound was used for the next reaction without purification

Sources & evidence

ORD record
ord-80676ec70c6d449eaf0d83da93a1f346
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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