反应详情

To a solution of 6-((6-(1-ethoxyvinyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline in MeOH (30 mL) was added excess 3N HCl solution. The solution was stirred at rt overnight and neutralized with saturated NaHCO3 solution. Organic solvent was evaporated and the residue was extracted with EtOAc three times. Organic layers were combined, washed with brine and dried over Na2SO4. Solvent was evaporated and the crude was purified by column chromatography (DCM:MeOH=95:5) to give the title compound as yellow solid (51.3%). LCMS (method B): [MH]+=304.1, tR=1.708 min.

1. customOrganic solvent was evaporated
2. extractionthe residue was extracted with EtOAc three times
3. washwashed with brine
4. dry with materialdried over Na2SO4
5. customSolvent was evaporated
6. customthe crude was purified by column chromatography (DCM:MeOH=95:5)