Methylamine → HCID 178483385, compound

HRID 1959842Notes

Reaction equation

HRID 1959842 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178509116HCID 178509116, compound

Product 1

HCID 178483385HCID 178483385, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Workup

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Sources & evidence

ORD record
ord-ba9730bcfda44e219843ae63e21a3455
Source dataset
uspto-grants-2013_04
Patent number
US08410272B2

Reaction notes

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