Tetrahydro-4H-pyran-4-ol → HCID 66730471, compound

HRID 1959967Notes

Reaction equation

HRID 1959967 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1.CC1C=CC(S(O[CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)(=O)=O)=CC=1>>[CH2:25]([O:24][CH2:23][CH2:22][O:21][CH2:20][CH2:19][O:7][CH:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 14004864HCID 14004864, compound

Product 1

HCID 66730471HCID 66730471, compoundYield 85.3%

Procedure

Using tetrahydro-4-pyranol (0.784 mL, 8.23 mmol) and 2-[2-(benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate (1.92 g, 5.48 mmol) synthesized in Reference Example 6 (6a), the desired title compound (1.31 g, yield 85%) was obtained by the same method as in Reference Example 2 (2a).

Sources & evidence

ORD record
ord-a30f792e4860403ca0941869ad4b750f
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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