Guanidine → HCID 178449181, compound

HRID 1961335Notes

Reaction equation

HRID 1961335 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH:6]([N:9]=[C:10]=[N:11][CH:12]([CH3:14])[CH3:13])([CH3:8])[CH3:7].NC(N)=N>>[CH2:1]([NH:5][C:10]([NH:11][CH:12]([CH3:14])[CH3:13])=[N:9][CH:6]([CH3:8])[CH3:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 3520GuanidineHCID 8007ButylamineHCID 12734Diisopropylcarbodiimide2×

Product 1

HCID 178449181HCID 178449181, compound

Procedure

A mixture of 33 g of N-butylamine (0.45 mol) and 19 g of diisopropylcarbodiimide (0.15 mol) is refluxed for 3 h 30. GC analysis then shows a conversion of greater than 99.50 of the diisopropylcarbodiimide. The colorless final mixture is concentrated at 60° C. under 20 mbar for 2 h so as to give 29 g of a colorless and virtually odorless liquid of low viscosity, corresponding to the expected guanidine (yield 96.70).

Workup

  1. temperatureis refluxed for 3 h 30
  2. concentrationThe colorless final mixture is concentrated at 60° C. under 20 mbar for 2 h so as
  3. customto give 29 g of a colorless and virtually odorless liquid of low viscosity

Sources & evidence

ORD record
ord-b56ad776a5244edaad8a714d4a69c0da
Source dataset
uspto-grants-2013_04
Patent number
US08415018B2

Reaction notes

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