Hydrochloric Acid → HCID 59436460, compound

HRID 1961396Notes

Reaction equation

HRID 1961396 reaction equation
[F:1][C:2]1[S:6][C:5]([NH:7][C:8]([C@@H:10]2[CH2:14][C@H:13]([OH:15])[CH2:12][N:11]2C(OC(C)(C)C)=O)=[O:9])=[N:4][CH:3]=1.Cl.O1CCOCC1>CO>[F:1][C:2]1[S:6][C:5]([NH:7][C:8]([C@@H:10]2[CH2:14][C@H:13]([OH:15])[CH2:12][NH:11]2)=[O:9])=[N:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59436458HCID 59436458, compound

Product 1

HCID 59436460HCID 59436460, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (2S,4S)-tert-butyl 2-(5-fluorothiazol-2-ylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate (1.42 g, 4.29 mmol) in MeOH (40 mL) was added 4N HCl in dioxane (10.71 mL, 42.9 mmol). The reaction mixture was stirred at RT for 2 h and concentrated. The residue was used for the next step without purification. LC/MS [M+H]+: 232; Ret time (Method F): 0.51 min.

Workup

  1. concentrationconcentrated
  2. customThe residue was used for the next step without purification
  3. custom0.51 min.

Sources & evidence

ORD record
ord-6e0f863b3be4413eb1b9176cd118445b
Source dataset
uspto-grants-2013_04
Patent number
US08415340B2

Reaction notes

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