反应详情

温度

120 °C

2-Amino-3-pyridine carboxaldehyde (1.0 g, 8.19 mmol) was suspended in diethylmalonate (6.2 ml, 41.0 mmol) in a screw cap pressure tube. Piperidine (1.6 ml, 16.4 mmol) was added and the tube was sealed. The mixture was heated to 120° C. for 3.0 hours. The mixture was allowed to cool. The precipitate formed was filtered and washed with Et2O to yield 1.62 g (91%) of the title compound.

1. customcap pressure tube
2. customthe tube was sealed
3. temperatureto cool
4. customThe precipitate formed
5. filtrationwas filtered
6. washwashed with Et2O