Ethanethiol → HCID 178477504, compound

HRID 1961624Notes

Reaction equation

HRID 1961624 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([NH:13][C@H:14]2[CH2:19][CH2:18][C@H:17]([CH2:20][C:21](O)=[O:22])[CH2:16][CH2:15]2)=[O:12])=[CH:3][CH:2]=1.C(Cl)(=O)C(Cl)=O.[CH2:30]([SH:32])[CH3:31].C([Li])CCC.C([O-])(O)=O.[Na+]>ClCCl.C(COC)OC>[CH2:30]([S:32][C:21](=[O:22])[CH2:20][C@H:17]1[CH2:16][CH2:15][C@H:14]([NH:13][C:11]([C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)=[O:12])[CH2:19][CH2:18]1)[CH3:31]

Participants

8

Reactant 5

HCID 6343EthanethiolHCID 65578Oxalyl chlorideHCID 516892Sodium BicarbonateHCID 178418339ButyllithiumHCID 178525567HCID 178525567, compound

Product 1

HCID 178477504HCID 178477504, compoundYield 78.9%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

2.19 g of Trans-{4-[(Quinoline-4-carbonyl)-amino]-cyclohexyl}-acetic acid (7 mmol) was added in 1300 mL of dichloromethane. Then 1.8 mL of oxalyl chloride is added (21 mmol). The suspension was heated to reflux for 3 hours and then the cloudy mixture is concentrated under vacuum. The residue is taken up in 500 mL of dichloromethane as a suspension and (1.28 g, 21 mmol) sodium ethylthiolate freshly prepared from 1.45 mL of ethanothiol and 12.07 mL of Butyl lithium (1.6 M in toluene) at 0° C. and by stirring in dimethoxyethane (20 mL) for 1 h at room temperature. The reaction mixture was stirred overnight. NaHCO3 was added and the organic phase was extracted three times with dichloromethane. The organic phases were dried and concentrated and the residue was chromatographied with heptane/AcOEt 1:1 to AcOEt to yield the title compound as a solid (1.97 g, 78.9% yield). MS (m/e): 357.3 (M+H+).

Workup

  1. temperatureThe suspension was heated
  2. temperatureto reflux for 3 hours
  3. concentrationthe cloudy mixture is concentrated under vacuum
  4. extractionthe organic phase was extracted three times with dichloromethane
  5. customThe organic phases were dried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-3d800172db354671bed81d61cf98889a
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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