反应详情

To DMF (5.0 ml) was added sodium hydride (53 mg, 1.3 mmol) and the solution stirred at room temperature for 30 min. 5-Bromoindoline (240 mg, 1.2 mmol) was added and the solution was stirred at room temperature for 30 min. Methanesulfonyl chloride (94 ul, 1.2 mmol) was added and the solution stirred at room temperature overnight, then concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3 to give the title compound (202 mg, 60%).

1. stirringthe solution was stirred at room temperature for 30 min
2. stirringthe solution stirred at room temperature overnight
3. concentrationconcentrated in vacuo
4. customThe crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3