反应详情

温度

80 °C

A mixture of the product from Example 76, Part D (0.100 g, 0.382 mmol), N-methylmethane-sulfonamide (45.9 mg, 0.421 mmol) and potassium carbonate (0.127 g, 0.918 mmol) in N,N-dimethylacet-amide (5 mL). The mixture was stirred at 80° C. for 11 h, cooled to room temperature and partitioned between diethylether and water (3×), dried over mgSO4, filtered and concentrated in vacuo to give the title compound as a colorless waxy solid (0.128 g, quant.).

1. temperaturecooled to room temperature
2. custompartitioned between diethylether and water (3×)
3. customdried over mgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo