反应详情

A mixture of 5-bromo-1-fluoro-2-methyl-3-nitro-benzene (9.96 g) and iron powder (11.9 g) in ethanol (100 ml), water (20 ml) and concentrated hydrochloric acid (2 ml) was heated at reflux for one hour. After cooling, the reaction mixture was filtered through hyflo (calcined diatomaceous earth) and concentrated. The residue was purified by chromatography on silica gel (ethyl acetate/cyclohexane 1:9 to 1:4). Yield: 7.06 g of 5-bromo-3-fluoro-2-methyl-phenylamine as an oil.

1. temperaturewas heated
2. temperatureat reflux for one hour
3. temperatureAfter cooling
4. filtrationthe reaction mixture was filtered through hyflo (calcined diatomaceous earth)
5. concentrationconcentrated
6. customThe residue was purified by chromatography on silica gel (ethyl acetate/cyclohexane 1:9 to 1:4)