Sodium hydride → HCID 86232756, compound

HRID 1962510Notes

Reaction equation

HRID 1962510 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[CH:7]=[O:8].[H-].[Na+].C1OCCOCCOCCOCCOC1.Cl.[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([S:33](Cl)(=[O:35])=[O:34])[CH:28]=1>>[CH3:1][C:2]1[N:3]([S:33]([C:29]2[CH:28]=[N:27][CH:32]=[CH:31][CH:30]=2)(=[O:35])=[O:34])[CH:4]=[CH:5][C:6]=1[CH:7]=[O:8]

Participants

5

Reactant 4

HCID 24758Sodium hydrideHCID 3633615-Crown-5HCID 53245852-methyl-1H-pyrrole-3-carbaldehydeHCID 12571517Pyridine-3-sulfonyl chloride hydrochloride

Product 1

HCID 86232756HCID 86232756, compound

Procedure

By a similar reaction as in Reference Example 44 and using 2-methyl-1H-pyrrole-3-carbaldehyde (1.10 g), sodium hydride (60% in oil, 1.20 g), 15-crown-5 (6.0 mL) and pyridin-3-ylsulfonyl chloride hydrochloride (3.22 g), the title compound was obtained as white crystals (yield 1.10 g, 44%).

Workup

  1. customBy a similar reaction as in Reference Example 44

Sources & evidence

ORD record
ord-a35336974acb4304aebbc3dad4474320
Source dataset
uspto-grants-2013_04
Patent number
US08415368B2

Reaction notes

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