Sodium periodate → HCID 66732333, compound

HRID 1963124Notes

Reaction equation

HRID 1963124 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH3:12])=[O:10])[CH:5]([CH2:13][C:14]([CH3:22])([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH3:15])[CH2:4]1.I([O-])(=O)(=O)=[O:24].[Na+]>[Ru](Cl)(Cl)Cl>[CH3:12][O:11][C:9]([N:6]1[CH2:7][CH2:8][CH:3]([C:2]([OH:24])=[O:1])[CH2:4][CH:5]1[CH2:13][C:14]([CH3:22])([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH3:15])=[O:10]

Participants

4

Reactant 2

HCID 23667635Sodium periodateHCID 66732283HCID 66732283, compound

Product 1

HCID 66732333HCID 66732333, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 61850Ruthenium trichlorideCatalyst

Procedure

The compound was prepared as described in Reference Compound 4, Step 5 starting from methyl 4-(hydroxymethyl)-2-(2-methyl-2-phenylpropyl)piperidine-1-carboxylate (8.0 g, 26.2 mmol), sodium periodate (16.8 g, 78.6 mmol) and ruthenium(III) chloride (0.12 g, 0.58 mmol), which resulted in the title compound (7.24 g, 87%). MS m/z 318 (M−H)−.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e7b8a5504c08408ca998b289f8c9fd14
Source dataset
uspto-grants-2013_04
Patent number
US08415378B2

Reaction notes

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