反应详情

To an acetonitrile (20 mL) solution of 4-nitrophenol (0.423 g; 3.04 mmol) and potassium carbonate (1.11 g; 8.02 mmol), 4-bromo-1-butene (0.827 g; 6.13 mmol) was added, and the mixture was refluxed and then reacted for 17 hours. After completion of the reaction, the solution was filtrated by Celite, and then the filtrate was concentrated under a reduced pressure. The residue was purified by flash column chromatography using methylene chloride, and then the effluent was concentrated to obtain 4-(3-butenyloxy)nitrobenzene (1) (0.571 g, 97% of yield, a light yellow oil) represented by the following formula.

1. temperaturethe mixture was refluxed
2. customreacted for 17 hours
3. customAfter completion of the reaction
4. filtrationthe solution was filtrated by Celite
5. concentrationthe filtrate was concentrated under a reduced pressure
6. customThe residue was purified by flash column chromatography
7. concentrationthe effluent was concentrated