Benzaldehyde → N-Benzylidene(piperidin-4-yl)methanamine

HRID 1963802Notes

Reaction equation

HRID 1963802 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[NH:14]1[CH2:15][CH2:16][CH:11]([CH2:10][N:9]=[CH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 235274-(Aminomethyl)piperidine

Product 1

HCID 11820173N-Benzylidene(piperidin-4-yl)methanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Benzaldehyde (4.6 g; 0.044 mol) was added dropwise to a solution of 4-aminomethylpiperidine (5.0 g; 0.044 mol) in toluene (20 ml). The solution thus obtained was stirred for 3 h at room temperature. Then the solvent was removed by evaporation at reduced pressure and the residue was taken up twice with toluene to give the desired product that was used as such without further purification.

Workup

  1. customThe solution thus obtained
  2. customThen the solvent was removed by evaporation at reduced pressure

Sources & evidence

ORD record
ord-44fbf3dbd5fd4a169f29a44f7e72412c
Source dataset
uspto-grants-2013_04
Patent number
US08415476B2

Reaction notes

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