Iodine → HCID 178516519, compound

HRID 19658Notes

Reaction equation

HRID 19658 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].[I:15]I.OS([O-])(=O)=O.[K+]>O>[OH:1][C:2]1[C:7]([I:15])=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1

Participants

6

Reactant 4

HCID 807IodineHCID 11430Potassium CarbonateHCID 516920Potassium bisulfateHCID 178516518HCID 178516518, compound

Product 1

HCID 178516519HCID 178516519, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2,4-dihydroxypyridine (1.0 eq), K2CO3 (1.0 eq), and water was stirred at 100° C. so that it became homogeneous. With continued stirring and heating, I2 (1.0 eq) was added in portions, causing the evolution of gas. When the solid I2 was consumed, the mixture was cooled and acidified with aqueous KHSO4 (1.0 eq), generating a precipitate. The precipitate was collected by filtration, rinsed with water, and stored under high vacuum, to give 2,4-dihydroxy-3-iodopyridine.

Workup

  1. stirringWith continued stirring
  2. temperatureheating
  3. customWhen the solid I2 was consumed
  4. temperaturethe mixture was cooled
  5. filtrationThe precipitate was collected by filtration
  6. washrinsed with water

Sources & evidence

ORD record
ord-c55d733421a444529c3510bfaeac415c
Source dataset
uspto-grants-2010_06
Patent number
US07745454B2

Reaction notes

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