Triethylamine → HCID 86643309, compound

HRID 1965938Notes

Reaction equation

HRID 1965938 reaction equation
[NH:1]([CH2:7][CH2:8][CH2:9][C:10]#[N:11])[CH2:2][CH2:3][CH2:4][C:5]#[N:6].C(N(CC)CC)C.[CH2:19]([O:21][P:22](Cl)([O:24][CH2:25][CH3:26])=[O:23])[CH3:20]>ClCCl>[CH2:19]([O:21][P:22]([N:1]([CH2:2][CH2:3][CH2:4][C:5]#[N:6])[CH2:7][CH2:8][CH2:9][C:10]#[N:11])([O:24][CH2:25][CH3:26])=[O:23])[CH3:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13139Diethyl chlorophosphateHCID 56072Butyronitrile, 4,4'-iminodi-

Product 1

HCID 86643309HCID 86643309, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,3′-Iminodipropyl cyanide (50 mmol) was dissolved in dichloromethane (100 ml). To the system was added triethylamine (10 ml), and then dropwise added at room temperature diethoxyphosphoryl chloride (50 mmol) in dicholormethane (60 ml) solution. The mixture was allowed to react at room temperature over night. The resultant was concentrated and performed to column chromatography (eluant: dichloromethane/methanol system) to obtain 9.7 g of a colorless transparent oily substance, yield 75%, MS[M]+=259.2 m/e.

Workup

  1. customto react at room temperature over night
  2. concentrationThe resultant was concentrated
  3. customto obtain 9.7 g of a colorless transparent oily substance, yield 75%, MS[M]+=259.2 m/e

Sources & evidence

ORD record
ord-406a77f3225d4c1c8144ebea728c750f
Source dataset
uspto-grants-2013_04
Patent number
US08420626B2

Reaction notes

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