Hydrochloric Acid → HCID 21081086, compound

HRID 1965951Notes

Reaction equation

HRID 1965951 reaction equation
C([NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:8][CH2:7]1)(=O)C.Cl>CC(C)=O>[NH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21081084HCID 21081084, compound

Product 1

HCID 21081086HCID 21081086, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

13 g of 3-[4-(acetylamino-methyl)-cyclohexyl]-propionic acid are added to 200 ml of semi-concentrated aqueous hydrochloric acid and the resulting solution is refluxed overnight. The mixture is combined with acetone, recrystallised and the precipitate is separated off. When the mother liquor is concentrated step by step further fractions of the crystallin product are isolated. The fractions are combined, recrystallised with isopropanol and then dried.

Workup

  1. temperaturethe resulting solution is refluxed overnight
  2. customrecrystallised
  3. customthe precipitate is separated off
  4. concentrationWhen the mother liquor is concentrated step by step further fractions of the crystallin product
  5. customare isolated
  6. customrecrystallised with isopropanol
  7. customdried

Sources & evidence

ORD record
ord-3f685ec3784541c3a95290ada173894c
Source dataset
uspto-grants-2013_04
Patent number
US08420630B2

Reaction notes

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