Sodium Bicarbonate → HCID 57868833, compound

HRID 1966135Notes

Reaction equation

HRID 1966135 reaction equation
[CH3:1][C:2]1([S:5]([N:8]2[CH2:11][CH:10]([O:12][Si](CC)(CC)CC)[CH2:9]2)(=[O:7])=[O:6])[CH2:4][CH2:3]1.C(=O)(O)[O-].[Na+]>O1CCCC1.O.C(O)(=O)C>[CH3:1][C:2]1([S:5]([N:8]2[CH2:9][CH:10]([OH:12])[CH2:11]2)(=[O:7])=[O:6])[CH2:4][CH2:3]1

Participants

6

Reactant 2

HCID 516892Sodium BicarbonateHCID 57868838HCID 57868838, compound

Product 1

HCID 57868833HCID 57868833, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-[(1-methylcyclopropyl)sulfonyl]-3-[(triethylsilyl)oxy]azetidine (0.125 g, 0.41 mmol) in tetrahydrofuran (3 mL), water (1 mL) and acetic acid (1 mL) was stirred at room temperature for four hours. The mixture was neutralized by pouring into a solution of sodium bicarbonate. The product was extracted with ethyl acetate, the extracts were washed with brine, dried over sodium sulfate, decanted and concentrated to afford product, used without further purification (64 mg, 82%).

Workup

  1. extractionThe product was extracted with ethyl acetate
  2. washthe extracts were washed with brine
  3. dry with materialdried over sodium sulfate
  4. customdecanted
  5. concentrationconcentrated
  6. customto afford product
  7. customused without further purification (64 mg, 82%)

Sources & evidence

ORD record
ord-3b8bdcc603d842358740e525cdfd6291
Source dataset
uspto-grants-2013_04
Patent number
US08420629B2

Reaction notes

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