HCID 57516788, compound → HCID 57516787, compound

HRID 1966613Notes

Reaction equation

HRID 1966613 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]([CH3:25])([CH3:24])[CH2:8][N:9](CC1C=CC=CC=1)CC1C=CC=CC=1)C>CCO.[OH-].[OH-].[Pd+2]>[CH3:24][C:7]1([CH3:25])[CH2:8][NH:9][C:4](=[O:3])[CH2:5][O:6]1

Participants

4

Reactant 1

HCID 57516788HCID 57516788, compound

Product 1

HCID 57516787HCID 57516787, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

(2-Dibenzylamino-1,1-dimethyl-ethoxy)-acetic acid ethyl ester (Example 172, step 1) was hydrogenated in EtOH with Pd(OH)2 for 16 hours at 60° C. The desired 6,6-dimethyl-morpholin-3-one (585 mg, 60% purity, quant.) was obtained as a colorless liquid, MS: m/e=129 (M+H+) and used in the next step without further purification.

Sources & evidence

ORD record
ord-fb65578b63a646bba6117bdd89271d8c
Source dataset
uspto-grants-2013_04
Patent number
US08420661B2

Reaction notes

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