Tetrahydrofuran → HCID 58542068, compound

HRID 1966777Notes

Reaction equation

HRID 1966777 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.C([N:15]([CH:18]([CH3:20])[CH3:19])CC)(C)C.[CH2:21]1COC[CH2:22]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:15][C:18]([CH3:19])([CH3:20])[CH2:21][CH3:22])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzene

Product 1

HCID 58542068HCID 58542068, compound

Procedure

To a solution of 4-bromo-1-fluoro-2-nitrobenzene (200 μL, 1.62 mmol) and tert-amyamine (170 mg, 1.95 mmol) in THF (5.0 mL) is added diisopropylethyl amine (500 μL, 2.87 mmol). The reaction mixture is allowed to cool to room temperature and is concentrated under reduced pressure to afford crude (4-bromo-2-nitro-phenyl)-(1,1-dimethyl-propyl)-amine (600 mg).

Workup

  1. concentrationis concentrated under reduced pressure

Sources & evidence

ORD record
ord-9da9e56074ae47c6bdd7c2e7168502bd
Source dataset
uspto-grants-2013_04
Patent number
US08420655B2

Reaction notes

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