Potassium Carbonate → HCID 86647601, compound

HRID 1966824Notes

Reaction equation

HRID 1966824 reaction equation
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:20]3[CH2:24][C:23]4([CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)[O:22][N:21]=3)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].Cl.[NH2:31][OH:32].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:20]3[CH2:24][C:23]4([CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)[O:22][N:21]=3)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][C:16](=[N:31][OH:32])[CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 66732777HCID 66732777, compound

Product 1

HCID 86647601HCID 86647601, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanone (0.025 gm, 0.063 mmol) (example 17), hydroxylamine hydrochloride (0.008 gm, 0.126 mmol) and potassium carbonate (0.043 gm, 0.315 mmol) were taken in acetonitrile and the reaction mixture was stirred at room temperature for about 6 h. Excess of solvent was removed under reduced pressure and solid separated was washed with hexane and dried in vacuum.

Workup

  1. customExcess of solvent was removed under reduced pressure and solid
  2. customseparated
  3. washwas washed with hexane
  4. customdried in vacuum

Sources & evidence

ORD record
ord-afc0593b16924845ad453b1b53c4fdd4
Source dataset
uspto-grants-2013_04
Patent number
US08420666B2

Reaction notes

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